Under WHO CNS5, pediatric-type low-grade gliomas are subdivided into MYB- or MYBL1- (from the avian myelobalstosis viral oncogene) altered diffuse gliomas, mitogen-activated protein kinase (MAPK)-altered diffuse gliomas (commonly BRAF or FGFR1 alterations), angiocentric glioma (MYB::QKI fusion), or polymorphous low-grade neuroepithelial tumor of the young (FGFR2 fusions) (9). Here, MYBL1 is linked to central nervous system cancer.