MGMT and glioblastoma: Although MGMT methylation status may be more impactful in determining the ideal regimen in elderly patients with GBM (27), it is often used in upfront clinical trials to determine eligibility and should ideally be done in all GBM patients regardless of age.GBM in AYA is treated with maximal safe resection, followed by concomitant chemoradiation and adjuvant temozolomide according to the Stupp protocol (28).