Figure 4D clearly shows a significant (P <0.001) decrease of RAD51 foci in the presence of ATR inhibitor at tmax in ARID1A- cell line SW48 (P<0.01). We also confirmed above results from other ARID1A+ (HCT15, Colo320DM) and ARID1A- (RKO, LS180) CRC cell lines (Supplement Figure S12). The gene discussed is ATR; the disease is colorectal carcinoma.