Besides, the translation of RPN2, TCF4, KDM7A, HPSE, TMPRSS4, and E2F1 was also suppressed by miR-1258 overexpression, according to recent research, which prevented cell invasion and migration in HCC (21, 23), CRC (27), BC (35, 40), and TC (43). Here, HPSE is linked to breast cancer.