Surprisingly, both CD24 and CD47, two classic ligands of “don’t eat me” signal, were notably upregulated on tumor cells from mice received anti-CD20 antibody (Figure 6A), whereas comparable expression levels of their receptors were observed on macrophages, Siglec-10 and SIRPα, respectively (Data not shown). The gene discussed is MS4A1; the disease is neoplasm.