HK2 and neuroblastoma: Similarly, HNF4α has been shown to promote glycolysis, glucose uptake, lactic acid production and ATP levels in neuroblastoma cells, and the underlying mechanism involved hexokinase 2 (HK2) and Solute Carrier Family 2 Member 1 (SLC2A1) and the heterogeneous nuclear ribonucleoprotein U (hnRNPU) (11).