In pancreatic cancer, HNF4α deletion led to a glycolytic energy metabolism transition from typical pancreatic adenocarcinoma to squamous pancreatic cancer, in which Fructose-Bisphosphate Aldolase A (ALDOA), Hexokinase 1 (HK), and Glycogen Synthase Kinase 3 Beta (GSK3β) genes are upregulated. The gene discussed is HK1; the disease is pancreatic adenocarcinoma.