Contrary to the conclusion above, the expression of HNF4α in colon cancer leads to the decreased expression of oncogenic factors Lysine Demethylase 1 (ALSD1), SET Domain Containing 1A, Histone Lysine Methyltransferase (SETD1A), Protein Arginine Methyltransferase 1 (PRMT1), FOXM1, Protein Tyrosine Kinase 2 (FAK) and Snail Family Transcriptional Repressor 1(SNAI1), and inhibits the tumor-formation of HCT116 cells (35). This evidence concerns the gene SETD1A and malignant colon neoplasm.