STAT3 and hepatocellular carcinoma: Oligo-fucoidan, a sulfated polysaccharide, inhibited HCC growth by binding to the Asialoglycoprotein Receptor (ASGR) which led to Signal Transducer And Activator of Transcription 3 (STAT3) phosphorylation, and then p-STAT3 induced the transcription of the HNF4α (23).