In pancreatic cancer, HNF4α deletion led to a glycolytic energy metabolism transition from typical pancreatic adenocarcinoma to squamous pancreatic cancer, in which Fructose-Bisphosphate Aldolase A (ALDOA), Hexokinase 1 (HK), and Glycogen Synthase Kinase 3 Beta (GSK3β) genes are upregulated. This evidence concerns the gene HK1 and pancreatic neoplasm.