We also analyzed the expression levels of HNF4α in different tumors from the TCGA database and found that HNF4α is upregulated in most gastrointestinal tumor tissues when compared to their matched normal tissues, including colon and rectal adenocarcinoma, esophageal cancer, stomach cancer and pancreatic cancer. The gene discussed is HNF4A; the disease is familial pancreatic carcinoma.