HNF4A and familial pancreatic carcinoma: Although the TCGA database showed that HNF4α expression level was elevated in pancreatic cancer tissues, Camolotto’s results demonstrated that HNF4α inhibited tumor growth and promoted epithelial development through directly inhibiting expression of Sine Oculis Homeobox Homolog (SIX) 4 and SIX1, two markers of mesodermal/neuronal lineage expressed in basal-like subtypes (46).