In addition, TACE could lead to necrosis of tumor tissue and upregulate the expression of hypoxia-inducible factor 1-α (HIF-1α), vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF), which could stimulate tumor recurrence or growth (2, 34, 42, 61). Here, VEGFA is linked to neoplasm.