Concerning the clinical correlation (Figure 2D), ITGB5 expression was clearly upregulated in patients with a T3&T4 stage or distant metastases compared to patients with T1&T2 stage or non-distant metastases, which highlighted the invasive and metastatic potential of ITGB5 expression in pancreatic cancer. Here, ITGB5 is linked to pancreatic neoplasm.