Finally, the risk scores of each PC patient were calculated using the following method: AGRS = -4.47765657690985*CLOCK+1.29384446467155*NUP160+0.846130542021257*MIS18BP1+1.06447461483067*DYNC1LI2-0.137000461457667*MAPK1+1.57474598539145*SETD2-4.05360227520656*ARID4B+0.566257977207755*ARID1A+1.13167548982397*ZNF654+12.0526647311552*SYNJ1+3.88187142257071*C18orf25-2.81564312424355*MBTPS2-0.577996066831003*XIAP-6.43690052943485*ZNF678. The gene discussed is ZNF654; the disease is pachyonychia congenita.