Pathway enrichment analysis among the two clusters found that cluster 1 was enriched in pathways related to cell-cycle regulation and DNA damage repair such as “G2M checkpoint”, “E2F targets”, and “DNA repair”, while cluster 2 was mostly enriched in tumor-related pathways including “notch signaling”, “p53 pathway”, “KRAS signaling up”, and “estrogen response early” (Figure 3G). The gene discussed is TP53; the disease is neoplasm.