Cox regression multivariate analysis further demonstrated that multiple tumors (P=0.002), maximal tumor diameter≥ 5cm (P=0.01), major venous thrombosis (VP3 and VP4, P=0.001), sarcopenia (P=0.048), AFP ≥ 200 ng/ml (P <0.001), and albumin<3.5mg/dL(P=0.024) were independent poor prognostic factors for overall survival in HCC patients receiving TACE (Table 4). This evidence concerns the gene AFP and neoplasm.