On the other hand, multiple tumors (P=0.006), maximal tumor diameter ≥ 5cm (P <0.001), alpha-fetoprotein ≥ 200ng/dL (P <0.001), portal venous thrombosis (P=0.002), major venous thrombosis (VP3 and VP4, P<0.001), and albumin <3.5mg/dL(P=0.054) were found to be significantly associated with a worse OS. This evidence concerns the gene ALB and Venous thrombosis.