PRKDC and alveolar rhabdomyosarcoma: Interestingly, our preclinical data also indicate that OTX015 exposure can enhance the radiosensitivity of ARMS cells by inducing a drastic G2 cell cycle arrest, which was correlated to a permanent DNA damage (upregulation of γ-H2AX) and to the inability of tumoral cells to repair it (alteration of RAD51, ATM, and DNA-PK protein expression).