RECK and neoplasm: Among them, five biomarkers correlated with improved OS (elevated CD8+/Foxp3+ ratio, H-TERT promoter mutations, and high expression of SNF5 protein, c-MET receptor, and miRNA-1), eight biomarkers correlated with improved PFS (high Immunoscore, elevated PD1+ Tumor-Infiltrating Lymphocytes (TIL), high expression of PHLPP1 protein, Raf-1 and ERK proteins, elevated MMP-9/RECK protein ratio, and the high nuclear expression of miRNA-1290 and mi-RNA-1237-3p) and, 2 biomarkers were linked with both PFS and OS (elevated PD-L1+ TIL and high preoperative serum albumin level).