It was previously shown that pro-inflammatory macrophages promoted cancer cell binding onto lymphatic ECs (50), likely via IL-1β secretion, whereas macrophages treated with carcinoembryonic antigen (CEA) were able to promote colon carcinoma HT-29 cancer cell binding onto ECs (51), but no data were generated without pre-treatment of macrophages with CEA. This evidence concerns the gene CEACAM5 and cancer.