Spautin-1, an inhibitor of USP10/13 (25), may inhibit EGFR-related signaling pathways, inducing activation of the MKK4/JNK/Bax axis and inactivation of the MEK1/2/ERK/cyclin D1 axis, leading to significant inhibition of PCa proliferation (59). This evidence concerns the gene USP10 and posterior cortical atrophy.