In addition to gene mutations, chromosomal changes and gene fusions related to this pathway were also identified, including the repeated amplification of chromosomal loci of the PI3K activator PSPN gene and mTOR regulator ULK1 gene, and the fusion of EWSR1 gene with BEND2 and FLI1 genes, which can activate mTOR signal and promote tumor formation (6). This evidence concerns the gene MTOR and neoplasm.