Hence, we treated pancreatic cancer cells with RSL3 (a well-known ferroptosis inducer that inhibits GPX4) in the presence of Wortmannin (WM, a well-known autophagosome inhibitor that supresses autophagosome) or Rapamycin (RA, a well-known autophagy activator that inhibits mTOR). The gene discussed is MTOR; the disease is familial pancreatic carcinoma.