GPX4 and familial pancreatic carcinoma: Hence, we treated pancreatic cancer cells with RSL3 (a well-known ferroptosis inducer that inhibits GPX4) in the presence of Wortmannin (WM, a well-known autophagosome inhibitor that supresses autophagosome) or Rapamycin (RA, a well-known autophagy activator that inhibits mTOR).