Surprisingly, the ssGSEA research found unique high level of adaptive immune cells including activated CD8 T cell, natural killer cell, and gamma delta T cell in CuproptosisCluster C, while marked enrichment of immunosuppressive cells and innate immune cells including macrophage, monocyte, regulatory T cell, Th1 cell, Th17 cell, and dendritic cell, eosinophil, and mast cell in CuproptosisCluster B. Activated CD8 T cell by neoantigen is the predominate effector cell exerting tumor killing and at the hotspot of antitumor immunotherapy (54). Here, CD8A is linked to neoplasm.