PDHA1 and colorectal cancer: The results indicated that the expression level of FDX1, LIAS, DLD, DLAT, PDHA1, MTF1, GLS, DBT, and DLST was lower in colorectal cancer tissues compared with normal tissues (Figure 1D), consistent with the CNV alteration, which implies that CNV may be the dominant effector on the expression alteration of cuproptosis regulators.