Using a mouse model with tetracycline-inducible expression of CXCL1 from astrocytes, our lab demonstrated that sustained CXCL1 expression from the CNS results in increased neutrophil infiltration that correlates with increased clinical disease and demyelination in the JHMV model of viral-induced demyelination as well as in experimental autoimmune encephalomyelitis (EAE) the prototypic pre-clinical model of autoimmune-mediated demyelination. Here, CXCL1 is linked to experimental autoimmune encephalomyelitis.