IGHE and hereditary spastic paraplegia: Previous studies have confirmed that children with HSP may have elevated IgE (35), and our results also suggest that both GI bleeding and GI non-bleeding children showed elevated IgE (182.0 ng/mL vs. 90.4 ng/mL, P = 0.028), but the elevated IgE was more pronounced in GI bleeding children and IgE ≥ 136 ng/mL scored 2 points in the scoring model.