TNF and arthritic joint disease: Taken together, IL-17 is a critical pro-nociceptive cytokine in mBSA-induced arthritis through the promotion of neutrophil migration and production of various pro-inflammatory mediators, such as TNF-α, IL-1β, CXCR1/2 chemokine ligands, MMPs, endothelins, prostaglandins, and sympathetic amines.