GSDMB and nonpapillary renal cell carcinoma: To explore the role of CASP4 and GSDMB in ccRCC proliferation, migration, and invasion in vitro, we constructed two siRNA specifically targeting CASP4 (siCASP4-1, si-CASP4-2) and GSDMB (siGSDMB-1, siGSDMB-2) respectively, and overexpressing vector (OE-CASP4 and OE-GSDMB) (Figures 10A, B).