The expression levels of AIM2, CASP1, CASP4, CASP5, GSDMA, GSDMB, GSDMC, GZMA, GZMB, IFI16, MEFV, MLKL, NAIP, NLRC4, NLRP1, NLRP6, NLRP7, NLRP12, NOD2, PYCARD, RBCK1, TLR3, TNIP1, TRADD, TRAF2, ZBP1 were upregulated in tumor samples, while only the expression level of NLRP2 was downregulated in tumor samples. The gene discussed is CASP4; the disease is neoplasm.