Furthermore, GSEA indicated that a high NPG score is predominantly associated with tumor progression and immunity, including (Figures 4C, D): reactome chemokine receptors bind chemokines, reactome regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps, reactome immunoregulatory interactions between a lymphoid and a non lymphoid cell, hallmark kras signaling dn, hallmark epithelial mesenchymal transition, hallmark coagulation. This evidence concerns the gene KRAS and neoplasm.