Studies have shown that for many respiratory diseases described in this review, some medicinal plants and inhibitors, by inhibiting the expression of NLRP3 inflammasome or caspase-1, can inhibit the pathway of pyroptosis, reduce the degree of pyroptosis, reduce inflammatory reaction and cell damage, to slow down the progression of the disease and improve the prognosis, this method may become a new target for the treatment of respiratory diseases. Here, NLRP3 is linked to respiratory system disorder.