Recently, human caspase-4 and its mouse homolog caspase-11 were found up-regulated in SARS–CoV-2 infections, in which CASP4 expression was demonstrated to correlate with the severity of human SARS–CoV-2 infection, however, SARS–CoV-2–induced inflammation triggered by caspase-4/11 were largely independently of GSDMD (156). This evidence concerns the gene CASP4 and COVID-19.