(105) recently found that depletion of Th2 cytokines (IL-5 and IL-13) inhibited NLRP3 inflammasome responses, and reduced steroid-insensitive AHR in experimental obesity-induced asthma, however, inhibition of NLRP3 inflammasome had no effect on IL-5 or IL-13 responses in experimental asthma, which highlighted the potential utility of T2 cytokine-targeted biologics. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.