(67) found that transforming growth factor-β-activated kinase 1 (TAK1) inhibition by pathogenic Yersinia infection in macrophages triggers caspase-8 mediated GSDMD cleavage and resultant pyroptosis independent of caspase-1/11, the lysosomal Rag-Ragulator is found necessary for caspase-8 mediated pyroptosis, which may instruct the inflammatory response to Yersinia, providing an alternative method of triggering pyroptosis. Here, CASP8 is linked to Yersinia infectious disease.