GSDMB and asthma: revealed that 17q12-21 single nucleotide polymorphisms regulating GSDMB expression in airway epithelial cells, but not in peripheral blood mononculear cells, play a major role in childhood-onset asthma based on genetic and gene expression data in African Americans and European Americans, which indicated that GSDMB may be the leading candidate gene at the asthma locus (112).