(168) found that in the orthotopic tracheal transplantation mouse BO model, NLRP3 inflammasome inhibitor MCC950 blocked the activation of NLRP3 inflammasome to reduce the production of pyroptosis-related cytokines IL-1β and IL-18, thus regulating the balance of Th1/Th17 and Treg cells and improving BO lesions. The gene discussed is IL1B; the disease is bronchiolitis obliterans syndrome.