Toluene Diisocyanate (TDI) is a known respiratory sensitizer linked to occupational asthma, MCC950 has also shown efficacy in a TID-induced asthma model, in which it was found to inhibit NLRP3 activation and reduce downstream inflammatory mediators (such as caspase-1, IL-1β, and IL-18) levels, alleviating AHR, airway inflammation, and airway remodeling (102). The gene discussed is IL18; the disease is asthma.