ADA2 and vascular disorder: We generated (Flp-IN) CHO cell lines that stably expressed recombinant human wild-type (WT) ADA2 and two pathogenic loss-of-(catalytic) function variants located in different domains of the protein (Figure 1) and associated with different clinical phenotypes: G47R is a variant frequently associated with DADA2 with vasculopathy being a common feature (12), and L351Q is a variant we discovered in two DADA2 patients (siblings) that, unlike the G47R variant, was associated with severe, early-onset disease that was fatal for one child.