Except for MKI67 monocytes, PBMC-derived monocytes bifurcated to ascites-resident macrophage populations (ADAP2 and MARCO macrophages) and tumor-resident populations (MKI67 monocytes and APOE macrophages) (Figure 3D), suggesting that peripheral monocytes may migrate to ascites and tumors, and be educated as different subtypes in the TIME. This evidence concerns the gene ADAP2 and neoplasm.