APOE and neoplasm: Except for MKI67 monocytes, PBMC-derived monocytes bifurcated to ascites-resident macrophage populations (ADAP2 and MARCO macrophages) and tumor-resident populations (MKI67 monocytes and APOE macrophages) (Figure 3D), suggesting that peripheral monocytes may migrate to ascites and tumors, and be educated as different subtypes in the TIME.