Interestingly, genes involved in cell apoptosis (CAPN2, ATM, CHEK1, PRKDC, RAD21 and TNFRSF10A) and DNA damage repair (ALKBH2, H2AFX, POLE2) pathways were significantly upregulated in the responding melanomas, indicating that tumour intrinsic factors in responding melanomas were not as extremely altered as in non-responding tumours (Figure 7). This evidence concerns the gene POLE2 and neoplasm.