SETD2 and melanoma: Our data indicate that most of the driver mutant genes are involved in DNA damage repair pathways (Figure 1), such as TP53, NOTCH1, PTEN, CREBBP, MAP2K1, SF3B1, MET, ATM, ALK, SETD2, ERCC2, BAP1, DNMT3A, SMARCA4, ATRX, RB1, CDK12, and IDH1, indicating genomic instability in melanoma.