While T cells obtained from AML patients at primary diagnosis exhibit increased IFN-γ production, strongly reduced levels of IFN-γ were observed in CD8+ T cells from patients who developed relapsed AML after allogeneic HCT (allo-HCT), whereas patients without relapse did not show reduced IFN-γ production (169). The gene discussed is IFNG; the disease is acute myeloid leukemia.