Thus, the potential induction of PD-L1 and PD-L2 by IFN-γ may have unfavorable consequences, because the PD-1/PD-L1/PD-L2 axis helps the tumor to maintain an immunosuppressive microenvironment, thereby promoting immune evasion and survival of cancer cells (177). This evidence concerns the gene PDCD1LG2 and neoplasm.