In vitro, IL-10 treatment of AML blasts inhibited spontaneous AML blast proliferation and colony formation by negatively affecting the production and secretion of pro-leukemic cytokines (IL-1α, IL-1β, TNF-α, GM-CSF, GM-CSF, and IL-6) (74–76, 191). The gene discussed is IL10; the disease is acute myeloid leukemia.