CAR-T cells harboring an IL-10 peptide structure within their antigen-binding domain were shown to recognize and bind to the IL-10 receptor of multiple AML cell lines (MV4-11, Kasumi-1, U937, THP-1 and MOLM-13) and primary AML cells, thereby inducing the CAR T-cell mediated killing of these cells in vitro and in vivo (196). Here, IL10 is linked to acute myeloid leukemia.