Moreover, while IFN-γ can restore T cell-mediated anti-cancer immunity and the surface expression of HLA class II molecules, the loss of which has been shown to impair AML recognition by donor T cells (170), IFN-γ is also capable of promoting PD-L1 and PD-L2 expression in AML (171, 172). This evidence concerns the gene CD274 and acute myeloid leukemia.