While production of IL-8 can be induced by various stimuli, including lipopolysaccharide, IL-1, and TNF in healthy cells, many tumor cells express IL-8 constitutively (142) or in a hypoxia-, acidosis-, or chemotherapy-induced manner, leading to anti-apoptotic and growth-supporting MAPK, PI3K, FAK and SRC18 signaling (143). The gene discussed is CXCL8; the disease is neoplasm.