Using meta-analysis, we demonstrated that the MMP2 pooled SMD in 5 distinct GEO datasets was 0.54, 95% CI (0.13.0.96) (Figure 5I), and ultimately, meta-analysis revealed that the COL3A1 pooled SMD of late stages of COVID-19 was 0.84, 95% CI (0.24,1.44) when compared to controls (Figure 5L). The gene discussed is MMP2; the disease is COVID-19.