The top five cancers with a high frequency of PTPRT/PTPRD mutations were SKCM (43.02%), esophagogastric adenocarcinoma (EAC) (35.21%), undifferentiated stomach adenocarcinoma (STAD) (30.77%), cervical squamous cell carcinoma (CESC) (26.77%), and NSCLC (26.12%), as shown in Figure 2A. The gene discussed is PTPRT; the disease is cancer.