Recently, in another Genome-Wide Association study of 1622 AIH-1 patients, Li et al. confirmed the previous association of AIH with HLA, in this case, SNP RS6932730 located in the intronic region of the HLA-B gene, but also found associations with two novel loci, CD28-CTLA4-ICOS and SYNPR (29). This evidence concerns the gene CTLA4 and autoimmune hepatitis.