All those genes are involved in biological process associated to Chagas disease: nervous system (LHX6, POU6F2, MDGA1, DISC1, PCSK9), immune system (ZMIZ, HLA-DRB1), Wnt pathway (DISC1), ion transport (KCNK15, PCSK9), striated muscles (SMYD3) or ATP metabolic process (ATP5S). This evidence concerns the gene SMYD3 and Chagas disease.