On the other side, there is a set of soluble proteins that have lower values compared to the average concentration of soluble proteins studied in both CLL and MBLhi [13.84% (9/65) and 7.69% (5/65), respectively], such as IL-13, IL-1β, IL-7, and IL-8 (Supplementary Figure 2A). Here, IL1B is linked to B-cell chronic lymphocytic leukemia.