Some of the significant soluble immune factors are sIL-2R, CXCL9/MIG, sTIMD-4 for MBLhi vs. CLL-PFT, sIDO, IL-18 and sCD30 for c-CLL vs. CLL-PFT or sLAG-3, and IFN-γ for c-CLL vs. CLL-TFT. Here, IL18 is linked to B-cell chronic lymphocytic leukemia.