As Table 2 showed, age and EDSS were independent factors in model 1 (including the covariates of age, history of hypertension and EDSS); while age and CSF titer of anti-AQP4 antibody were independent factors in model 2 (including the covariates of age, history of hypertension, CSF titer of anti-AQP4 antibody, CSF IgG, CSF IgA, CSF/serum albumin rate, serum albumin and EDSS). Here, AQP4 is linked to hypertensive disorder.