LAG3 and experimental autoimmune encephalomyelitis: On the other hand, in experimental autoimmune encephalomyelitis and adoptive transfer colitis models, adoptive transfer of LAG3 deficient Tregs failed to protect against disease despite normal trafficking and stable foxp3 expression suggesting that LAG3 can be required for Treg mediated suppression in certain autoimmune settings while it can be detrimental in others (186, 187).