TGFB1 and neoplasm: If so, a slow take over by the neoantigen-specific Tregs may gradually transform the clonal landscape of the TME for the intratumoral neoantigen-specific T cells via mechanisms such as antigen-specific suppression by pMHCII depletion and/or conversion into tumor-specific pTregs due to suboptimal antigen stimulus and elevated TGF-β as well as bystander mechanisms of suppression (40, 109).