described two distinct subsets of CD8+ Trm expressing KLRG1 and CD103, showing that CD103+ CD8+ Trm in Crohn’s disease patients exhibit a Th17-like phenotype, while highly proliferative KLRG1+ CD8+ Trm present with increased cytotoxic effector function and are overrepresented during acute inflammation (277). Here, KLRG1 is linked to Crohn disease.