Likewise, Huang and colleagues validated the anti-inflammatory and pro-angiogenic properties of human mesenchymal stem cell-derived exosomesmiRNA-21-5p for their application to promote ischemic tissue repair (103) and Pacini and colleagues investigated the role of human Gc protein-derived macrophage activating factor (GcMAF) in the context of deregulated angiogenesis in cancer in ovo (104). The gene discussed is GC; the disease is cancer.