Risk score were calculated based on the expression levels and matching coefficients of these 17 genes (risk score = U2AF1*(-0.2693) + SKP1*(-2.1119) + RAP1B*(-0.5732) + IRF9*(-0.9094) + RPL39*(0.51087) + CBS*(-0.3459) + SH3BP5*(-0.37226) + BDH1*(0.6100) + ANAPC15*(0.4592) + CCND2*(-0.3396) + ATP6V0C*(-3.1010) + FOLR2*(-1.0969) + RAPGEF3*(-1.4154) + ST8SIA3*(-1.6129) + PCP4*(0.3333) + MGST1*(-0.4300) + CSRP1*(0.3475)), and glioma patients were divided into low- and high-risk groups. The gene discussed is CBS; the disease is central nervous system cancer.