CD28 and cancer: The results of the correlation between AIM2 inflammasomes scores and 46 immune-activating genes in pan-cancer showed that the AIM2 inflammasomes score was positively correlated with KLRK1, CD27, TNFSF13B, CD86, CD48, TMIGD2, TNFRSF18, LTA, TNFRSF17, TNFRSF13B, TNFRSF4 CD40LG, CD28, CD70, KLRC1, CD80, TNFRSF9, IL2RA, TNFRSF8, C10orf54, TNFSF14, MICB, TMEM173, CD40, and ENTPD1 in the vast majority of tumors (all P < 0.05) (Figure 11C).