Meanwhile, by analyzing the correlation between the expression of AIM2i-RGs and methylation in 33 tumors, we also found that the expression of AIM2 was negatively correlated with methylation in SKCM, THCA, LUAD, ACC, COAD, BLCA, TGCT, LGG, KIRP, BRCA, Rectum adenocarcinoma Esophageal carcinoma (READ), LUSC, SARC, KIRC, LIHC, STAD, LAML, HNSC, CESC, UVM, ESCA, Mesothelioma (MESO), UCEC, PRAD, PAAD, KICH, PCPG, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC), THYM, and CHOL (all P < 0.05). The gene discussed is AIM2; the disease is diffuse large B-cell lymphoma.