AIM2 had significantly higher expression in DLBC, LAML, LUAD, LUSC, and PRAD and lower in BLCA, BRCA, CESC, COAD, ESCA, GBM, Head and Neck squamous cell carcinoma (HNSC), KIRC, LGG, OV, PAAD, SKCM, STAD, and THYM (all P < 0.05) (Figure 1B). The gene discussed is AIM2; the disease is head and neck squamous cell carcinoma.