Additionally, ESRD patients in the presence of hypomagnesemia have elevated levels of adiponectin, which plays a role in energy homeostasis and lipid/glucose metabolism (Markaki et al., 2012) and may correlate with ischemic heart disease (van de Wal-Visscher, Kooman & van der Sande, 2018). This evidence concerns the gene ADIPOQ and familial primary hypomagnesemia.