In fact, Tau protein has been implicated as the PI3K/AKT/mTOR pathway downstream effector to control neurite outgrowth, and its hyperphosphorylation is considered to be the basis of neuronal degeneration in Alzheimer’s disease (Tao et al., 2014; Yang et al., 2020). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.