RHOBTB2 and Global developmental delay: Functional studies in Drosophila sp., along with case reports of affected individuals, have linked missense RHOBTB2 protein variants to decreased Rho GTPase protein degradation, increased protein accumulation in the central nervous system, and subsequent neuronal degradation, conferring a phenotype of developmental delay and epileptic encephalopathy (Belal et al., 2018; Straub et al., 2018).