PAX8 and acute myeloid leukemia: In addition, since lncRNAs can modulate ADM resistance [13], which is critically related to the poor outcomes of AML patients [4], and PAX8-AS1 expression can reflect the poor prognosis of AML childhood, we hypothesized that PAX8-AS1 may be possibly implicated in ADM-resistant AML, thus impacting the prognosis of ADM-resistant patients.