S100B and neoplasm: In the present study, serum LDH, MIA, and S-100B levels of AJCC stage II, III, and IV were higher than those of stage I, serum LDH, those of stage III and IV were higher than those of stage II, those of stage IV were higher than those of stage III, suggesting the correlation of serum LDH, MIA, and S-100B levels with AJCC tumor stage.