To better understand the role of ANGPTL4 in lung adenocarcinoma, we selected GSE68465 for differential expression analysis and obtained 153 DEGs, of which the matrix metalloproteinase family (Matrix Metallopeptidase 1 (MMP1), MMP10, MMP12, MMP13), the chemokines subfamily (C-X-C Motif Chemokine Ligand 1 (CXCL1), CLCL5, CLCL8), and the collagen family (Collagen Type I Alpha 1 Chain (COL1A1), COL5A1, COL5A2, COL7A1, COL11A1) showed positive correlation with ANGPTL4. This evidence concerns the gene COL5A2 and lung adenocarcinoma.