Physical activity (PA) could decrease the levels of proinflammatory markers and promote the secretion of anti-inflammatory factors, such as interleukin-1 beta increased in hippocampal volume and serum with symptom improvement [58]; (2) effects on neurogenesis: autonomic nervous system dysfunction plays an important role in the connection between depression and outcomes in HF [59]. The gene discussed is IL1B; the disease is hydrops fetalis.