Through network pharmacology, this study found that Forsythoside A has 95 common genes in male infertility, including AKT1, ESR1, SRC, CASP3, EGFR, IGF1, MMP9, HSP90AA1, RHOA, ANXA5, MDM2, MAPK14, MMP2. This evidence concerns the gene MAPK14 and male infertility.