KEGG enriches 105 signal pathways, among them, phosphatidylinositol 3-kinase - serine/threonine kinase (PI3K-Akt) signaling pathway, MAPK signaling pathway, DNA-binding transcription factor (Rap1) signaling pathway, Endocrine resistance, FoxO signaling pathway, Estrogen signaling pathway, Ras signaling pathway, Relaxin signaling pathway, Focal adhesion, etc. are the main signaling pathways that Forsythoside A acts on male infertility, as shown in Figure 6. This evidence concerns the gene AKT1 and male infertility.