PLOD1 and polycystic ovary syndrome: Modern studies have shown that acupuncture stimulation acts on local skin, the excitation of peripheral nerves is transmitted to the central nervous system, releasing brain neurotransmitters or neuropeptides acting on the HPOA, promoting ovarian vascular dilatation and blood perfusion in ovarian arteries, elevating E and endorphin levels in peripheral blood, and regulating the serum levels of GnRH, LH, FSH, and PRL in PCOS patients [82].