PLOD1 and polycystic ovary syndrome: Lai et al. found that CC combined with CHM and acupuncture points RN4, RN3, and EX-CA1 could increase E2 levels, decrease LH and T levels, which can significantly increase PR in PCOS infertile patients compared with CC alone (PR: 46.5% vs. 30.2% P < 0.05) [66].