Functionally, reduction of circ_0109046 reduced the proliferative, migratory, and invasive abilities of A2780 cells and at the same time promoted apoptosis by enhancing the content of pro-apoptotic Bax protein and declining the level of anti-apoptotic Bcl-2 protein, indicating that circ_0109046 lack inhibited the malignant progression of ovarian cancer cells in vitro. The gene discussed is BCL2; the disease is ovarian cancer.