FAIM has been reported to exert its biological effects by reducing ubiquitination; FAIM was found to reduce the ubiquitination and degradation of XIAP via direct interaction [48], FAIM knockout led to the presentation of ubiquitinated aggregates in the retina [49], and FAIM protects glutaminase C from ubiquitination and induces cancer cell proliferation in lung adenocarcinoma [14]. Here, GLS is linked to cancer.