Several proteins, such as corticosteroid 11-b-dehydrogenase isoenzyme 1 (HSD11B1), estradiol 17-b-dehydrogenase 1, vitamin D3 receptor (VDR), insulin-like growth factor, glutathione S-transferase A1, SEC14-like protein 2, mineralocorticoid receptor, 72 kDa Type IV collagenase, oxysterol receptor LXR-alpha, and bile acid receptor, that are frequently targeted by the compounds may be the specific targets for GLQMW in patients with T2D. This evidence concerns the gene NR1H4 and type 2 diabetes mellitus.