Male VPA rats exhibited lower sensitivity to pain, increased repetitive/stereotypic-like activity, higher anxiety, a decreased level of social interaction, an increased basal level of corticosterone, decreased weight of the thymus, decreased proliferative response of splenocytes to concanavalin A, a lower interferon-gamma/IL-10 ratio, and increased production of nitric oxide by peritoneal macrophages, while female VPA rats displayed only increased repetitive/stereotypic-like activity and a decreased interferon-gamma/IL-10 ratio (Schneider et al., 2008). The gene discussed is IFNG; the disease is Anxiety.